Pharmacology Formulas
Pharmacology formulas explained with examples.
Drug half-life, dosing, clearance, and more.
Creatinine Clearance Formula (Cockcroft-Gault)
Cockcroft-Gault equation estimates kidney function: CrCl = [(140-age) × weight / (72 × SCr)] × 0.85 if female. Used for drug dosing in renal impairment.
Drug Half-Life Formula
Calculate drug concentration over time using half-life: C(t) = C₀ × (1/2)^(t/t½). Includes elimination rate constant and worked examples.
Loading Dose Formula
Loading dose = (Vd × C_target) / F. Calculate the initial drug dose needed to rapidly reach therapeutic concentration. With worked clinical examples.
Maintenance Dose Formula
Maintenance dose = Cl × Css × τ / F. Calculate the regular dose that maintains a steady-state drug concentration. Essential clinical pharmacokinetics.
Volume of Distribution Formula
Volume of distribution: Vd = Dose / C₀. Understand how widely a drug distributes in body tissues. Essential pharmacokinetics formula.